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My youngest brother has suffered with Schizophrenia for around twenty years & we have also tried him on many meds - some good, some not so good. The main problem is the anguish etc. he undergoes each time he has to be "weaned" off one med & put on another. This is because after a while they all lose their effect & periodically need changing - not so with Clozaril. After being on it for five years, he is still stable, although a recent lessening of his regular dose is causing some anxiety. We hope to have the dosage resumed as previous, but see no need at this time to change him from this excellent medication.

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Note: The antipsychotic agents considered were aripiprazole, asenapine, clozapine, olanzapine, iloperidone, paliperidone, quetiapine, risperidone, and ziprasidone.

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Undesirable alterations in lipids have occurred in patients treated with atypical antipsychotics, including clozapine tablets.

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Note: Drs. Lipner, Brossman, and Samonte had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

ANC is within an acceptable range described in the Prescribing Information or the prescriber has authorized the continuation of clozapine treatment for patients with an ANC that falls below the acceptable range when the prescriber determines the benefits exceed the risks of developing severe neutropenia prior to dispensing.

Providing false reassurance will not help the client get over his feelings of anxiety.

The base-line white-cell count was inversely related to the risk of agranulocytosis, but the effect of this association was small and not significant after adjustment for age and sex.

This result should be interpreted only as evidence of the effectiveness of clozapine tablets in delaying time to recurrent suicidal behavior and not a demonstration of the superior efficacy of clozapine tablets over olanzapine.

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Of those, 845 were from people whose heart stopped beating after a decision to withdraw life support; the rest were from braindead patients.

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Because the client has confusion and a short attention span and lacks concentration, a reality-orientation group is recommended to help her maintain an optimal level of functioning.

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Jing added. However, it is possible that there could be permanent damage.

Clozapine, asenapine, olanzapine, quetiapine, paliperidone, risperidone, sertindole, ziprasidone, zotepine, and aripiprazole are atypical antipsychotic drugs.

User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.

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The additional burden of clozapine side effects and WBC monitoring probably contributes to the very high rate of discontinuation found in this study group.

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Overall, metabolic disturbances appear to be greatest with clozapine and olanzapine, intermediate with quetiapine and low-potency FGAs, and lowest with aripiprazole, risperidone, ziprasidone, and high-potency FGAs.

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Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo, Although the causes of death in clinical trials were varied, most appeared to be cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature.

Caution should be used in administering CLOZARIL to patients having a history of seizures or other predisposing factors.

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The trough level will generally demonstrate a norclozapine level about half the clozapine level: if they are the same, the patient may not have taken their last dose.

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Patients were required to discontinue any antipsychotic drugs other than clozapine, any mood-stabilizing or antidepressant drugs, and any anticonvulsant drugs for at least two weeks before entry into the study (except for fluoxetine and electroconvulsive therapy, which were discontinued for at least four weeks before entry into the study).

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